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ImmuneNOVA

Development of CMTM6 inhibitors: Modulation of PDL1 for cancer treatment

ImmuneNOVA aims to establish preclinical proof-of-concept in in vivo oncology models and in relevant patient-derived in vitro cell models for a novel immune checkpoint inhibitor targeting CMTM6. This inhibitor blocks a known immune checkpoint axis, PD-1/PD-L1, by decreasing cell surface expression of PD-L1, and so potentiates anti-tumour immunity. This novel inhibitor can be used to treat advanced forms of cancer, such as lung cancer, skin cancer (melanoma) and kidney cancer.
Acronym: 
ImmuneNOVA
Project ID: 
11 889
Ranking: 
74
Cut-off: 
8
Start date: 
01-04-2018
Project Duration: 
36months
Project costs: 
3 521 350.00€
Technological Area: 
Pharmaceutical Products / Drugs
Market Area: 
Monoclonal Antibodies and Hybridomas