IMAGINe will develop a device for long-term imaging of organ-on-chip (OoC) applications. This enabling technology controls the environment (e.g. temperature, fluid flow) of OoC cultures to keep these viable during imaging. The IMAGINe device uniquely enables the long-term monitoring of cellular processes in the OoC. This will be validated using a human skin-on-chip and a metastatic melanoma-on-chip model, in combination with novel cell-based therapeutics to inhibit metastasis.